See also
Lithopone B301, Lithopone B311 powder’s 2 main components:
A legal additive in the United States, titanium dioxide is used in everything from food to consumer goods and the U.S. Food and Drug Administration says regulated use of the product as a color additive in food is safe within certain restrictions.
Breathing problems in offspring

In the same year (2019), the Netherlands Food and Consumer Product Safety Authority (NVWA) also delivered an opinion on possible health effects of food additive titanium dioxide, which highlighted the importance of examining immunotoxicological effects in addition to potential reprotoxicological effects.
Food safety experts in the European Union (EU) have recently updated their safety assessment of TiO2 as a food additive. In Europe, TiO2 is referred to as E171, in accordance with European labelling requirements for food additives. The EU expert panel took into account toxicity studies of TiO2 nanoparticles, which to this point had not been considered relevant to the safety assessment of TiO2 as a food additive.
Titanium is a metal element found naturally in the environment. When it's exposed to oxygen in the air, it forms titanium oxides that are contained in many minerals, sands, soils, and dusts.
TiO2 NPs appeared to be more toxic to nematode Caenorhabditis elegans than submicron-sized TiO2. At a concentration of 1 mg/l, 7 nm particles affected its fertility and survival rate and were more toxic than 20 nm anatase particles. Similarly, Hu et al. showed that rutile particles (10–20 nm), at concentrations above 1 g/kg soil, can be bio-accumulated in earthworms, where they induce oxidative stress, inhibit the activity of cellulase and induce DNA and mitochondrial damage.
Titanium dioxide is the most widely used whitening pigment in the world and has been linked to adverse health effects, particularly genotoxicity and intestinal inflammation. It is applied as food coloring and a whitening agent to a wide variety of foods, including chewing gum, cakes, candies, breads and ice cream.
If you want to avoid titanium dioxide, Stoiber and Faber urge consumers to try and avoid processed foods as best as you can.
4. Solar Cells The photovoltaic industry is another critical area where anatase TiO2 is making an impact. As a semiconductor, it plays a role in dye-sensitized solar cells (DSSCs), providing a pathway for improving energy conversion efficiency in sustainable energy solutions.
Oil absorption, g/ 100g
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Magnesium oxide (MgO). It is used as a curing agent and an acid scavenger in solvent-borne polychloroprene adhesives. It is a white powder with a high melting point. It has a greater ability to reflect visible light more efficiently than titanium dioxide
Acknowledgments

Manufacturers get titanium dioxide from minerals called brookite, rutile, and anatase. It's processed into a powder and refined to meet strict safety guidelines.
In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2. With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”